Sharh maqola

Polymer degradation and drug delivery in <scp>PLGA</scp>‐based drug–polymer applications: A review of experiments and theories

Yihan XuMaterials Science and Engineering Department University of Wisconsin‐Milwaukee Milwaukee Wisconsin 53211Chang Soo KimMaterials Science and Engineering Department University of Wisconsin‐Milwaukee Milwaukee Wisconsin 53211David M. SaylorDivision of Biology, Chemistry, and Materials Science Center for Devices and Radiological Health, U.S. Food and Drug Administration Silver Spring Maryland 20993Donghun KooMaterials Science R&D, MilliporeSigma Milwaukee Wisconsin 53209

2016en

ABI

Annotatsiya

Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact the degradation rates of PLGA polymers and concurrent drug release kinetics. This work is intended to provide a comprehensive and collective review of the physicochemical and physiological factors that dictate the degradation behavior of PLGA polymers and drug release from contemporary PLGA-based drug-polymer products. In conjunction with the existing experimental results, analytical and numerical theories developed to predict drug release from PLGA-based polymers are summarized and correlated with the experimental observations. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1692-1716, 2017.

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.1002/jbm.b.33648

Iqtiboslar va manbalar

2 ta iqtibos0 ta foydalanilgan manba

Koʻrsatkichlar — AkademScholar