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Biological activities of ophiobolin K and 6-epi-ophiobolin K produced by the endophytic fungus<i>Aspergillus calidoustus</i>

Camila Rodrigues de Carvalhoa Department of Microbiology , Federal University of Minas Gerais , Belo Horizonte , BrazilMariana de Lourdes Almeida Vieiraa Department of Microbiology , Federal University of Minas Gerais , Belo Horizonte , BrazilCharles L. Cantrellb USDA-ARS, Natural Products Utilization Research Unit , Oxford , MS , USADavid E. Wedgeb USDA-ARS, Natural Products Utilization Research Unit , Oxford , MS , USATânia Maria de Almeida Alvesc Laboratory of Chemistry of Natural Products, Oswaldo Cruz Foundation , Belo Horizonte , BrazilCarlos Leomar Zanic Laboratory of Chemistry of Natural Products, Oswaldo Cruz Foundation , Belo Horizonte , BrazilRaphael Sânzio Pimentad Laboratory of Environmental Microbiology, Federal University of Tocantins , Palmas , BrazilPolicarpo Ademar Salese Laboratory of Cellular and Molecular Parasitology, Oswaldo Cruz Foundation , Belo Horizonte , BrazilSilvane Maria Fonseca Murtae Laboratory of Cellular and Molecular Parasitology, Oswaldo Cruz Foundation , Belo Horizonte , BrazilÁlvaro J. Romanhae Laboratory of Cellular and Molecular Parasitology, Oswaldo Cruz Foundation , Belo Horizonte , BrazilCarlos A. Rosaa Department of Microbiology , Federal University of Minas Gerais , Belo Horizonte , BrazilLuiz Henrique Rosaa Department of Microbiology , Federal University of Minas Gerais , Belo Horizonte , Brazil

2015en

ABI

Annotatsiya

Endophytic fungi represent ubiquitous microbial organisms able to live in the tissues of different plants around the world and represent a prolific source of bioactive metabolites. In the present study, the endophytic fungus Aspergillus calidoustus was isolated from the medicinal plant Acanthospermum australe (Asteraceae), and identified using molecular, physiological and morphological methods. A methylene chloride crude extract of A. calidoustus has been produced and subjected to antifungal bioassay-directed fractionation which resulted in the isolation of the two bioactive compounds: ophiobolin K and 6-epi-ophiobolin K. These pure compounds displayed antifungal activity against fungal plant pathogens, protozoal activity against Trypanosoma cruzi, and cytotoxic activity against human tumoral cell lines. The results show that A. calidoustus was able to produce the antifungal and cytotoxic metabolites ophiobolin K and 6-epi-ophiobolin K, which may help the fungus to colonise and occupy the substratum as well as survive in natural environments.

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DOI: 10.1080/14786419.2015.1022777

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