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Epicoccolides: Antimicrobial and Antifungal Polyketides from an Endophytic Fungus <i>Epicoccum</i> sp. Associated with <i>Theobroma cacao</i>

Ferdinand Mouafo TalontsiInstitute of Organic and Biomolecular Chemistry, Georg August University, Tammannstrasse 2, 37077 Göttingen, Germany, http://wwwuser.gwdg.de/~hlaatsc/Birger DittrichInstitute of Inorganic Chemistry, Georg August University, Tammannstrasse 4, 37077 Göttingen, GermanyAnja SchüfflerInstitute of Biotechnology and Drug Research, 67663 Kaiserslautern, GermanyHan SunDepartment of NMR-Based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, GermanyHartmut LaatschInstitute of Organic and Biomolecular Chemistry, Georg August University, Tammannstrasse 2, 37077 Göttingen, Germany, http://wwwuser.gwdg.de/~hlaatsc/

2013en

ABI

Annotatsiya

Abstract In the search for new compounds to protect plants from fungi, an endophytic fungus, Epicoccum sp. CAFTBO, obtained from Theobroma cacao was found to produce three polyoxygenated polyketides, namely epicolactone ( 1 ) and epicoccolides A ( 2 ) and B ( 3 ), together with seven known metabolites. The structures of these compounds were elucidated by a combination of detailed spectroscopic and spectrometric analyses as well as DFT calculations of the electronic circular dichroism spectra and the single‐crystal X‐ray diffraction analysis of 1 . Compounds 1 – 3 showed potent antimicrobial activities and significant inhibitory effects on the mycelial growth of two peronosporomycete phytopathogens, Pythium ultimum and Aphanomyces cochlioides , and the basidiomycetous fungus Rhizoctonia solani .

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DOI: 10.1002/ejoc.201300146

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