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Scaffold Structural Microenvironmental Cues to Guide Tissue Regeneration in Bone Tissue Applications

Xuening ChenNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaHongyuan FanScholl of Manufacturing Science and Engineering, Sichuan University, Chengdu 610065, ChinaXiaowei DengLina WuNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaTao YiScholl of Manufacturing Science and Engineering, Sichuan University, Chengdu 610065, ChinaLinxia GuDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0526, USAChangchun ZhouNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaYujiang FanNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, ChinaXingdong ZhangNational Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China

2018en

ABI

Annotatsiya

In the process of bone regeneration, new bone formation is largely affected by physico-chemical cues in the surrounding microenvironment. Tissue cells reside in a complex scaffold physiological microenvironment. The scaffold should provide certain circumstance full of structural cues to enhance multipotent mesenchymal stem cell (MSC) differentiation, osteoblast growth, extracellular matrix (ECM) deposition, and subsequent new bone formation. This article reviewed advances in fabrication technology that enable the creation of biomaterials with well-defined pore structure and surface topography, which can be sensed by host tissue cells (esp., stem cells) and subsequently determine cell fates during differentiation. Three important cues, including scaffold pore structure (i.e., porosity and pore size), grain size, and surface topography were studied. These findings improve our understanding of how the mechanism scaffold microenvironmental cues guide bone tissue regeneration.

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DOI: 10.3390/nano8110960

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