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Toward understanding the selective anticancer capacity of cold atmospheric plasma—A model based on aquaporins (Review)

Dayun YanThe George Washington University Department of Mechanical and Aerospace Engineering, , Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052Annie TalbotThe George Washington University Columbian College of Arts and Sciences, , Phillips Hall, 801 22nd Street, NW, Suite 212, Washington, DC 20052Niki NourmohammadiThe George Washington University Department of Biological Sciences, , Lisner Hall, 2023 G Street, NW, Suite 340, Washington, DC 20052Jonathan H. ShermanThe George Washington University Neurological Surgery, , Foggy Bottom South Pavilion, 22nd Street, NW, 7th Floor, Washington, DC 20037Xiaoqian ChengThe George Washington University Department of Mechanical and Aerospace Engineering, , Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052Michael KeidarThe George Washington University Department of Mechanical and Aerospace Engineering, , Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052

2015en

ABI

Annotatsiya

Selectively treating tumor cells is the ongoing challenge of modern cancer therapy. Recently, cold atmospheric plasma (CAP), a near room-temperature ionized gas, has been demonstrated to exhibit selective anticancer behavior. However, the mechanism governing such selectivity is still largely unknown. In this review, the authors first summarize the progress that has been made applying CAP as a selective tool for cancer treatment. Then, the key role of aquaporins in the H2O2 transmembrane diffusion is discussed. Finally, a novel model, based on the expression of aquaporins, is proposed to explain why cancer cells respond to CAP treatment with a greater rise in reactive oxygen species than homologous normal cells. Cancer cells tend to express more aquaporins on their cytoplasmic membranes, which may cause the H2O2 uptake speed in cancer cells to be faster than in normal cells. As a result, CAP treatment kills cancer cells more easily than normal cells. Our preliminary observations indicated that glioblastoma cells consumed H2O2 much faster than did astrocytes in either the CAP-treated or H2O2-rich media, which supported the selective model based on aquaporins.

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Identifikatorlar

DOI: 10.1116/1.4938020

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