Transdermal delivery of allopurinol to acute hyperuricemic mice <i>via</i> polymer microneedles for the regulation of serum uric acid levels
Rui WangSchool of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, ChinaHan WangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaGuohua JiangInternational Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers, Hangzhou, 310018, ChinaYanfang SunCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310018, ChinaTianqi LiuSchool of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, ChinaLei Nie3BIO-BioMatter, École polytechnique de Bruxelles, Université Libre de Bruxelles (ULB), Brussels, BelgiumAmin Shavandi3BIO-BioMatter, École polytechnique de Bruxelles, Université Libre de Bruxelles (ULB), Brussels, BelgiumKhaydar E. YunusovInstitute of Polymer Chemistry and Physics, Uzbekistan Academy of Sciences, Tashkent, UzbekistanUladzislau E. AharodnikauResearch Institute for Physical Chemical Problems, Belarusian State University, Minsk, BelarusSergey O. SolomevichResearch Institute for Physical Chemical Problems, Belarusian State University, Minsk, Belarus
ABI
Annotatsiya
study demonstrated that the AP-loaded MN system can effectively reduce the SUA levels as oral administration with lower side effects, which will be conducive to reducing the adverse reactions and improving the bioavailability of AP. This MN-mediated strategy can facilitate transcutaneous hyperuricemia treatment and provide a new alternative for the exploration of clinical treatment of hyperuricemia and improvement of patient compliance.
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