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Liposomes: structure, composition, types, and clinical applications

Hamdi NsairatPharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, JordanDima KhaterDepartment of Chemistry, Faculty of Arts and Science, Applied Science Private University, Amman, JordanUsamah SayedDepartment of Biology, The University of Jordan, Amman, 11942, JordanFadwa OdehDepartment of Chemistry, The University of Jordan, Amman, 11942, JordanAbeer Al BawabDepartment of Chemistry, The University of Jordan, Amman, 11942, JordanWalhan AlshaerCell Therapy Center, The University of Jordan, Amman, 11942, Jordan

2022en

ABI

Annotatsiya

Liposomes are now considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, and low immunogenicity. Liposomes also proved to enhance drug solubility and controlled distribution, as well as their capacity for surface modifications for targeted, prolonged, and sustained release. Based on the composition, liposomes can be considered to have evolved from conventional, long-circulating, targeted, and immune-liposomes to stimuli-responsive and actively targeted liposomes. Many liposomal-based drug delivery systems are currently clinically approved to treat several diseases, such as cancer, fungal and viral infections; more liposomes have reached advanced phases in clinical trials. This review describes liposomes structure, composition, preparation methods, and clinical applications.

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DOI: 10.1016/j.heliyon.2022.e09394

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