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Immune Cell-Derived Exosomes in Inflammatory Disease and Inflammatory Tumor Microenvironment: A Review

Runmin ZhangDepartment of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of ChinaMuzhe LiDepartment of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of ChinaHuiyun LiDepartment of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of ChinaXun RanDepartment of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of ChinaFengtian JinDepartment of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of ChinaQingshan TanDepartment of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of ChinaZhiwei ChenDepartment of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of China

2024en

ABI

Annotatsiya

Inflammation is a common feature of many inflammatory diseases and tumors, and plays a decisive role in their development. Exosomes are extracellular vesicles unleashed by assorted types of cells, and it is widely known that exosomes of different immune cell sources play different functions. Exosome production has recently been reported for immune cells comprising macrophages, T cells, B cells, and dendritic cells (DCs). Immune cell-derived exosomes are involved in a variety of inflammatory responses.Herein, we summarize and review the role of macrophages, T cells, B cells, and dendritic cells (DC) in inflammatory diseases, with a focus on the role of immune cell-derived exosomes in osteoarthritis, rheumatoid arthritis, and the inflammatory tumor microenvironment (TME).These findings are expected to be important for developing new treatments for inflammatory diseases and ameliorating tumor-related inflammation.

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DOI: 10.2147/jir.s421649

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