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Intelligent Fe–Mn Layered Double Hydroxides Nanosheets Anchored with Upconversion Nanoparticles for Oxygen‐Elevated Synergetic Therapy and Bioimaging

Tao JiaKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. ChinaZhao WangKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. ChinaQianqian SunKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. ChinaShuming DongKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. ChinaJiating XuKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. ChinaFangmei ZhangKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. ChinaLili FengKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. ChinaFei HeKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. ChinaDan YangKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. ChinaPiaoping YangKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. ChinaJun LinKey Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. China

2020en

ABI

Annotatsiya

Abstract Multimodal synergistic therapy based on photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) has attracted increasing attention in cancer therapy. However, the scant therapeutic efficiency is always a barrier for further application. Herein, a smart tumor microenvironment (TME) responsive nanocatalysts are developed by adopting Fe–Mn layered double hydroxides (FeMn‐LDH) as an effective photothermal nanocarrier to load mesoporous silica and chlorin e6 (Ce6)‐covalently coated upconversion nanoparticles (UCSP) for multimodal imaging for directed therapy. Under acidic TME, FeMn‐LDH degrades into Fe 3+ and Mn 2+ ions to initiate a Fenton‐like reaction inducing CDT and enhancing magnetic resonance imaging. Additionally, Fe 3+ can decompose H 2 O 2 to oxygen (O 2 ), enhancing PDT guided by UCSP. As a representative noninvasive imaging probe, the upconversion luminescence will recover after decomposition of FeMn‐LDH, and provide high‐resolution upconversion luminescent imaging guidance for pinpointed PDT. Moreover, the photothermal properties of FeMn‐LDH can further enhance CDT effects. The synergistic therapy and multifunctional imaging can realize the integration of diagnosis and treatment.

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Identifikatorlar

DOI: 10.1002/smll.202001343

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