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Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy

Mengyu ChangSchool of Applied Chemistry and Engineering University of Sciences and Technology of China Hefei 230026 P. R. ChinaZhiyao HouGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation School of Basic Medical Sciences Guangzhou Medical University Guangzhou 511436 P. R. ChinaMan WangInstitute of Molecular Sciences and Engineering Shandong University Qingdao 266237 P. R. ChinaChunzheng YangSchool of Applied Chemistry and Engineering University of Sciences and Technology of China Hefei 230026 P. R. ChinaRuifeng WangState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. ChinaLi FangState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. ChinaDonglian LiuThe Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's Hospital Qingyuan 511518 P. R. ChinaTieli PengThe Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's Hospital Qingyuan 511518 P. R. ChinaChunxia LiInstitute of Molecular Sciences and Engineering Shandong University Qingdao 266237 P. R. ChinaJun LinSchool of Applied Chemistry and Engineering University of Sciences and Technology of China Hefei 230026 P. R. China

2021en

ABI

Annotatsiya

Photothermal therapy (PTT) is an extremely promising tumor therapeutic modality. However, excessive heat inevitably injures normal tissues near tumors, and the damage to cancer cells caused by mild hyperthermia is easily repaired by stress-induced heat shock proteins (HSPs). Thus, maximizing the PTT efficiency and minimizing the damage to healthy tissues simultaneously by adopting appropriate therapeutic temperatures is imperative. Herein, an innovative strategy is reported: ferroptosis-boosted mild PTT based on a single-atom nanozyme (SAzyme). The Pd SAzyme with atom-economical utilization of catalytic centers exhibits peroxidase (POD) and glutathione oxidase (GSHOx) mimicking activities, and photothermal conversion performance, which can result in ferroptosis featuring the up-regulation of lipid peroxides (LPO) and reactive oxygen species (ROS). The accumulation of LPO and ROS provides a powerful approach for cleaving HSPs, which enables Pd SAzyme-mediated mild-temperature PTT.

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Identifikatorlar

DOI: 10.1002/anie.202101924

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