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Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications

Mohammed Mahbubul MatinBioorganic and Medicinal Chemistry Laboratory, Faculty of Science, Department of Chemistry, University of Chittagong, Hathajari, Chittagong, BangladeshPriyanka MatinBioorganic and Medicinal Chemistry Laboratory, Faculty of Science, Department of Chemistry, University of Chittagong, Hathajari, Chittagong, BangladeshMd. Rezaur RahmanDepartment of Chemical Engineering and Energy Sustainability, Faculty of Engineering, Universiti Malaysia Sarawak, Kuching, MalaysiaTaïbi Ben HaddaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaFaisal A. AlmalkiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaShafi MahmudGenetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, BangladeshMohammed M. GhoneimDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi ArabiaMaha AlruwailyDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi ArabiaSultan AlshehriDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

2022en

ABI

Annotatsiya

Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Structurally, there are two types of five-membered triazoles: 1,2,3-triazole and 1,2,4-triazole. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities. These are also important in organocatalysis, agrochemicals, and materials science. Thus, they have a broad range of therapeutic applications with ever-widening future scope across scientific disciplines. However, adverse events such as hepatotoxicity and hormonal problems lead to a careful revision of the azole family to obtain higher efficacy with minimum side effects. This review focuses on the structural features, synthesis, and notable therapeutic applications of triazoles and related compounds.

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Identifikatorlar

DOI: 10.3389/fmolb.2022.864286

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