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Silver nanoparticles: Synthesis, medical applications and biosafety

Xu LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaYi-Yi WangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaJie HuangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaChun‐Yuan ChenDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaZhenxing WangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaHui XieDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
2020en
ABI

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), generation of reactive oxygen species (ROS), destruction of membrane structure. Despite these therapeutic benefits, their biological safety problems such as potential toxicity on cells, tissue, and organs should be paid enough attention. Besides, we briefly introduce a new type of Ag particles smaller than AgNPs, silver Ångstrom (Å, 1 Å = 0.1 nm) particles (AgÅPs), which exhibit better biological activity and lower toxicity compared with AgNPs. Finally, we conclude the current challenges and point out the future development direction of AgNPs.

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