Visible-light-catalyzed synthesis of 1,3-benzoxazines <i>via</i> formal [4 + 2] cycloaddition of oximes with <i>o</i>-hydroxybenzyl alcohols
Zhenjie QiDepartment of Engineering, Jining University, Qufu, Shandong, 273155, P. R. ChinaZhenyu AnCollege of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia, ChinaBing‐Bing HuangMingzhong WuSchool of Pharmacy, Liaocheng University, Liaocheng, ChinaQuansen WuDepartment of Engineering, Jining University, Qufu, Shandong, 273155, P. R. ChinaDongfang JiangHunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Provincial First-Class Applied Discipline (Pharmacy), Changsha, 410000, China
2023en
ABI
Annotatsiya
-QMs to oximes as a 1,2-dipole synthon, cyclization, and isomerization. The reaction exhibits a broad substrate scope and can be carried out under mild conditions. To demonstrate its synthetic usefulness, a gram-scale reaction was conducted, and the resulting 1,3-benzoxazine products were further transformed into other valuable compounds.
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