Hydrophobicity at Small and Large Length Scales
Ka LumDepartment of Chemistry, University of California, Berkeley, California 94720, and Institute for Physical Science and Technology and Department of Chemistry, University of Maryland, College Park, Maryland 20742David ChandlerDepartment of Chemistry, University of California, Berkeley, California 94720, and Institute for Physical Science and Technology and Department of Chemistry, University of Maryland, College Park, Maryland 20742John D. WeeksDepartment of Chemistry, University of California, Berkeley, California 94720, and Institute for Physical Science and Technology and Department of Chemistry, University of Maryland, College Park, Maryland 20742
1999en
ABI
Annotatsiya
We develop a unified and generally applicable theory of solvation of small and large apolar species in water. In the former, hydrogen bonding of water is hindered yet persists near the solutes. In the latter, hydrogen bonding is depleted, leading to drying of extended apolar surfaces, large forces of attraction, and hysteresis on mesoscopic length scales. The crossover occurs on nanometer length scales, when the local concentration of apolar units is sufficiently high, or when an apolar surface is sufficiently large. Our theory for the crossover has implications concerning the stability of protein assemblies and protein folding.
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