Enhanced Production of Surfactin from <i>Bacillus subtilis</i> by Continuous Product Removal and Metal Cation Additions
David G. CooperBiochemical Engineering, Faculty of Engineering Science, The University of Western Ontario, London, Ontario N6A 5B9, CanadaC.R. MacdonaldBiochemical Engineering, Faculty of Engineering Science, The University of Western Ontario, London, Ontario N6A 5B9, CanadaShamus DuffBiochemical Engineering, Faculty of Engineering Science, The University of Western Ontario, London, Ontario N6A 5B9, CanadaN. KosaricBiochemical Engineering, Faculty of Engineering Science, The University of Western Ontario, London, Ontario N6A 5B9, Canada
1981en
ABI
Annotatsiya
The lipopeptide, surfactin, is produced by Bacillus subtilis. A study has been made on large-scale production of this surfactant. A good yield was obtained from a glucose substrate fermentation by continuously removing the product by foam fractionation. The surfactin could be easily recovered from the collapsed foam by acid precipitation. The yield was also improved by the addition of either iron or manganese salts. Hydrocarbon addition to the medium, which normally increases biosurfactant production, completely inhibited surfactin production by B. subtilis.
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