Antifertility and Hormonal Properties of Certain Carotane Sesquiterpenes of<i>Ferula jaeschkeana</i>*
Man Mohan SinghCentral Drug Research Institute, Lucknow-226001, IndiaA. AgnihotriCentral Drug Research Institute, Lucknow-226001, IndiaSandeep GargCentral Institute of Medicinal and Aromatic Plants, Lucknow-226016, IndiaSantosh Kumar AgarwalCentral Institute of Medicinal and Aromatic Plants, Lucknow-226016, IndiaDeepak GuptaCentral Drug Research Institute, Lucknow-226001, IndiaGovind KeshriCentral Drug Research Institute, Lucknow-226001, IndiaVishal KambojCentral Drug Research Institute, Lucknow-226001, India
1988en
ABI
Annotatsiya
Of the 7 carotane sesquiterpenes of Ferula jaeschkeana Vatke evaluated, three jaeschkeanadiol esters (compounds 3, 5, and 6) showed contraceptive efficacy when administered orally on days 1-7 post coitum in rats. In ovariectomized immature female rats, however, the active compounds exhibited estrogenic activity and were devoid of antiestrogenic activity. Using a competitive protein binding assay, the compounds 3, 5, and 6 showed relative binding affinity of 0.01%, 5.75%, and 0.75% of 17β-estradiol, respectively, for rat uterine cytosol estrogen receptors.
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