Maqola

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

Rongbao GaoNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaBin CaoBeijing Chao-Yang Hospital, Beijing Institute of Respiratory Diseases, Capital Medical University, BeijingYunwen HuShanghai Public Health Clinical Center, Shanghai Medical College of Fudan University, ShanghaiZijian FengChinese Center for Disease Control and Prevention, BeijingDayan WangNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingWanfu HuAnhui Provincial Center for Disease Control and Prevention, Hefei, NanjingJian ChenShanghai Municipal Center for Disease Control and Prevention, ShanghaiZhijun JieFifth People's Hospital of Shanghai, Fudan University, ShanghaiHaibo QiuZhongda Hospital, Southeast University, NanjingKe XuJiangsu Provincial Center for Disease Prevention and Control, NanjingXuewei XuTaiwan Centers for Disease ControlHongzhou LuShanghai Public Health Clinical Center, Shanghai Medical College of Fudan University, ShanghaiWenfei ZhuNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingZhancheng GaoPeking University People's Hospital, BeijingNijuan XiangChinese Center for Disease Control and Prevention, BeijingYinzhong ShenNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingZebao HeFifth People's Hospital of Shanghai, Fudan University, ShanghaiYong GuFifth People's Hospital of Shanghai, Fudan University, ShanghaiZhiyong ZhangShanghai Public Health Clinical Center, Shanghai Medical College of Fudan University, ShanghaiYi YangZhongda Hospital, Southeast University, NanjingXiang ZhaoNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingLei ZhouChinese Center for Disease Control and Prevention, BeijingXiaodan LiNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingShumei ZouNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingYe ZhangChinese Center for Disease Control and Prevention, BeijingXiyan LiNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingLei YangNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingJunfeng GuoNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingJie DongNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingQun LiChinese Center for Disease Control and Prevention, BeijingLibo DongNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingYun ZhuChinese Center for Disease Control and Prevention, BeijingTian BaiNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingShiwen WangNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingPei HaoInstitute Pasteur of Shanghai, Chinese Academy of Sciences, ShanghaiWeizhong YangChinese Center for Disease Control and Prevention, BeijingYanping ZhangChinese Center for Disease Control and Prevention, BeijingJun HanNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingHongjie YuChinese Center for Disease Control and Prevention, BeijingDexin LiNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingGeorge F. GaoChinese Center for Disease Control and Prevention, BeijingGuizhen WuNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, BeijingYu WangChinese Center for Disease Control and Prevention, BeijingZhenghong YuanShanghai Public Health Clinical Center, Shanghai Medical College of Fudan University, ShanghaiYuelong ShuNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing

2013en

ABI

Annotatsiya

BACKGROUND: Infection of poultry with influenza A subtype H7 viruses occurs worldwide, but the introduction of this subtype to humans in Asia has not been observed previously. In March 2013, three urban residents of Shanghai or Anhui, China, presented with rapidly progressing lower respiratory tract infections and were found to be infected with a novel reassortant avian-origin influenza A (H7N9) virus. METHODS: We obtained and analyzed clinical, epidemiologic, and virologic data from these patients. Respiratory specimens were tested for influenza and other respiratory viruses by means of real-time reverse-transcriptase-polymerase-chain-reaction assays, viral culturing, and sequence analyses. RESULTS: A novel reassortant avian-origin influenza A (H7N9) virus was isolated from respiratory specimens obtained from all three patients and was identified as H7N9. Sequencing analyses revealed that all the genes from these three viruses were of avian origin, with six internal genes from avian influenza A (H9N2) viruses. Substitution Q226L (H3 numbering) at the 210-loop in the hemagglutinin (HA) gene was found in the A/Anhui/1/2013 and A/Shanghai/2/2013 virus but not in the A/Shanghai/1/2013 virus. A T160A mutation was identified at the 150-loop in the HA gene of all three viruses. A deletion of five amino acids in the neuraminidase (NA) stalk region was found in all three viruses. All three patients presented with fever, cough, and dyspnea. Two of the patients had a history of recent exposure to poultry. Chest radiography revealed diffuse opacities and consolidation. Complications included acute respiratory distress syndrome and multiorgan failure. All three patients died. CONCLUSIONS: Novel reassortant H7N9 viruses were associated with severe and fatal respiratory disease in three patients. (Funded by the National Basic Research Program of China and others.).

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.1056/nejmoa1304459

Iqtiboslar va manbalar

2 ta iqtibos0 ta foydalanilgan manba

Koʻrsatkichlar — AkademScholar