Biotransformation of (+)-androst-4-ene-3,17-dione
M. Iqbal ChoudharyH.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. [email protected]Sadia SultanUniversity of karachiMahmmud Tareq Hassan KhanUniversity of karachiAmsha YasinUniversity of karachiFarzana ShaheenUniversity of karachiAtta‐ur RahmanUniversity of karachi
2004en
ABI
Annotatsiya
Fermentation of (+)-androst-4-ene-3,17-dione (1) with Curvularia lunata for 10 days yielded five oxidative and reductive metabolites, androsta-1,4-diene-3,17-dione (2), 17beta-hydroxyandrosta-1,4-dien-3-one (3), 11alpha-hydroxyandrost-4-ene-3,17-dione (4), 11alpha,17beta-dihydroxyandrost-4-en-3-one (5) and 15alpha-hydroxyandrosta-1,4-dien-17-one (6). The structures of these metabolites were elucidated on the basis of spectroscopic techniques. These microbially transformed products were assayed against the clinically important enzymes, tyrosinase and prolyl endopeptidase.
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