Studies on Aconitum Species V. Constituents of Aconitum yesoense var. macroyesoense (Nakai) Tamura

Five new CZO-diterpenoid alkaloids, 12-acetyldehydro-Iucidusculine, 12-acetyllucidusculine. 15-benzoylpseudakobu8ine. 1 5 -v e r a t r o y i p s e o d o k o b ~~i n e , and Yesoxine and 14 known alkaloids were isolated from A. yesoense v a r .macravesoense (Nakai) Tanura.Structures of those compounds were determined on the basis of their spectral and chemical data.Structure of an unusual epoxide, yesoxine, was determined by X-ray analysis and was a first example having an epoxy group at C(16 and 17).The isolation and structure elucidation o f six alkaloids, dehYdrolucidusculine (1). N -d e e t h y i d e h y d r ~i ~c i d u s c u l i n e(2), kabusine (3).pseudokobusine (4).delcosine (5).and 14-acetyldelcosine ( 6 ) from A. yesoense var.macroyesoense (Nakai) Tamura were reported in our p r e v i o u s paper.'We have continued to Investigate the constituents o f this plant and isolated five new diterpenoid alkaloids, 12-acetyldehydroiucidu-Scuiine ( T ) , 12-aeetyllucidusculine ( 8 ) .15-benzoyl~seudokobusine ( 9 ) .15-veratroyl-Pseudokabusine (10).and a novel epoxide (11) named as yesaxine, together with eight known alkaloids, iucidueculine ( 1 2 ) ~~~. lucicuiine ( 1 3 ) ~. 1-acetylluciculine (14)5, 14-acetylbrovniine ( 1 5 ) ~~ brawniine ( 1 6 ) ~. virescenine ~1 7 ) ~, isotalatiridine -

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