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Light‐Responsive Hierarchically Structured Liquid Crystal Polymer Networks for Harnessing Cell Adhesion and Migration

Gülistan KoçerBioinspired Molecular Engineering Laboratory MIRA Institute for Biomedical Technology and Technical Medicine and Molecular Nanofabrication Group MESA+ Institute for Nanotechnology Department of Science and Technology University of Twente 7500 AE Enschede The NetherlandsJeroen ter SchiphorstFunctional Organic Materials and Devices Department of Chemical Engineering and Chemistry Eindhoven University of Technology 5612 AE Eindhoven The NetherlandsMatthew HendrikxFunctional Organic Materials and Devices Department of Chemical Engineering and Chemistry Eindhoven University of Technology 5612 AE Eindhoven The NetherlandsHailu G. KassaUniversity of Mons (UMONS) Laboratory for Chemistry of Novel Materials Center for Innovation and Research in Materials and Polymers (CIRMAP) Research Institute for Materials Science and Engineering Place du Parc, 20 B‐7000 Mons BelgiumPhilippe LeclèreFunctional Organic Materials and Devices Department of Chemical Engineering and Chemistry Eindhoven University of Technology 5612 AE Eindhoven The NetherlandsAlbertus P. H. J. SchenningFunctional Organic Materials and Devices Department of Chemical Engineering and Chemistry Eindhoven University of Technology 5612 AE Eindhoven The NetherlandsPascal JonkheijmBioinspired Molecular Engineering Laboratory MIRA Institute for Biomedical Technology and Technical Medicine and Molecular Nanofabrication Group MESA+ Institute for Nanotechnology Department of Science and Technology University of Twente 7500 AE Enschede The Netherlands

2017en

ABI

Annotatsiya

Extracellular microenvironment is highly dynamic where spatiotemporal regulation of cell-instructive cues such as matrix topography tightly regulates cellular behavior. Recapitulating dynamic changes in stimuli-responsive materials has become an important strategy in regenerative medicine to generate biomaterials which closely mimic the natural microenvironment. Here, light responsive liquid crystal polymer networks are used for their adaptive and programmable nature to form hybrid surfaces presenting micrometer scale topographical cues and changes in nanoscale roughness at the same time to direct cell migration. This study shows that the cell speed and migration patterns are strongly dependent on the height of the (light-responsive) micrometer scale topographies and differences in surface nanoroughness. Furthermore, switching cell migration patterns upon in situ temporal changes in surface nanoroughness, points out the ability to dynamically control cell behavior on these surfaces. Finally, the possibility is shown to form photoswitchable topographies, appealing for future studies where topographies can be rendered reversible on demand.

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Identifikatorlar

DOI: 10.1002/adma.201606407

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