In vivo metabolic pathway of liquiritin in rats
Dong Shi-qState Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research
2014en
ABI
Annotatsiya
Objective To study the in vivo metabolic pathways of liquiritin(LQ) in rats. Methods An HPLC-QTRAP-MS method was established and applied to identify the metabolites of LQ in bile, urine, feces, and plasma after ig administration of LQ(300 mg/kg) to rats. Results A total of nine metabolites were found in rats. The major metabolic pathway of LQ was deglucosidation to liquiritigenin(LG) and dehydration, glucuronidation, and sulfation of LG. Conclusion LQ undergoes extensive phases I and II metabolism in rats. The major metabolites of LQ are LG and its glucuronides and sulfates.
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