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1,3,4‐Thiadiazole and its Derivatives: A Review on Recent Progress in Biological Activities

Abhishek JainPharmaceutical Chemistry Research Laboratory Department of Pharmaceutical Sciences Dr. Hari Singh Gour University Sagar Madhya Pradhesh 470 003 IndiaSimant SharmaPharmaceutical Chemistry Research Laboratory Department of Pharmaceutical Sciences Dr. Hari Singh Gour University Sagar Madhya Pradhesh 470 003 IndiaAnkur VaidyaPharmaceutical Chemistry Research Laboratory Department of Pharmaceutical Sciences Dr. Hari Singh Gour University Sagar Madhya Pradhesh 470 003 IndiaVeerasamy RavichandranFaculty of Pharmacy AIMST University Semeling 08100 Kedah MalaysiaRam Kishore AgrawalPharmaceutical Chemistry Research Laboratory Department of Pharmaceutical Sciences Dr. Hari Singh Gour University Sagar Madhya Pradhesh 470 003 India
2013en
ABI

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The 1,3,4-thiadiazole nucleus is one of the most important and well-known heterocyclic nuclei, which is a common and integral feature of a variety of natural products and medicinal agents. Thiadiazole nucleus is present as a core structural component in an array of drug categories such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antineoplastic, and antitubercular agents. The broad and potent activity of thiadiazole and their derivatives has established them as pharmacologically significant scaffolds. In this study, an attempt has been made with recent research findings on this nucleus, to review the structural modifications on different thiadiazole derivatives for various pharmacological activities.

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