The use of molecularly imprinted polymers for the multicomponent determination of endocrine‐disrupting compounds in water and sediment

The method employing molecularly imprinted polymers for the extraction and clean up of endocrine-disrupting compounds (estrogens, bisphenol A, and alkylphenols) from water and sediment is described. The identical extraction/clean-up and LC-MS/MS condition were used for the analysis of both types of samples. The method showed high recoveries ranging from 90 to 99% with excellent precision (intrabatch: 3.6-9.3%; interbatch: 5.6-11.4% for water; intrabatch: 4.3-8.5%; interbatch: 6.1-9.6% for sediment). The LOD was in the range of 0.7-1.9 ng/L and 0.3-0.6 ng/g for water and sediment, respectively. Overall extraction on molecularly imprinted polymers substantially enhanced sample clean-up. The difference in efficiency of clean-up was particularly pronounced when a large sample volume/weight was extracted and analyzed. Finally, the method was successfully applied for the analysis of 20 water and sediment samples.

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