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Natural Products from Endophytic Microorganisms

Gary A. StrobelDepartment of Plant Sciences, Montana State University, Bozeman, Montana 59717, and Department of Chemistry, University of Utah, Salt Lake City, Utah 84112Bryn DaisyDepartment of Plant Sciences, Montana State University, Bozeman, Montana 59717, and Department of Chemistry, University of Utah, Salt Lake City, Utah 84112Uvidelio CastilloDepartment of Plant Sciences, Montana State University, Bozeman, Montana 59717, and Department of Chemistry, University of Utah, Salt Lake City, Utah 84112James K. HarperDepartment of Plant Sciences, Montana State University, Bozeman, Montana 59717, and Department of Chemistry, University of Utah, Salt Lake City, Utah 84112
2004en
ABI

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Endophytic microorganisms are to be found in virtually every plant on earth. These organisms reside in the living tissues of the host plant and do so in a variety of relationships ranging from symbiotic to pathogenic. Endophytes may contribute to their host plant by producing a plethora of substances that provide protection and ultimately survival value to the plant. Ultimately, these compounds, once isolated and characterized, may also have potential for use in modern medicine, agriculture, and industry. Novel antibiotics, antimycotics, immunosuppressants, and anticancer compounds are only a few examples of what has been found after the isolation and culturing of individual endophytes followed by purification and characterization of some of their natural products. The prospects of finding new drugs that may be effective candidates for treating newly developing diseases in humans, plants, and animals are great. Other applications in industry and agriculture may also be discovered among the novel products produced by endophytic microbes.

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