Structures of KS-501 and KS-502, the new inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase.
Tohru YasuzawaTokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., JapanYutaka SaitohTokyo Research Laboratories, Kyowa Hakko Kogyo Co., LtdHiroshi SanoTokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd
1990en
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The structures of KS-501 and KS-502, new inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, were determined to be 2-(beta-D-galactofuranosyloxy)-6-heptyl-4-hydroxybenzoic acid 3-heptyl-5-hydroxyphenyl ester and 2-(beta-D-galactofuranosyloxy)6-heptyl-4-hydroxybenzoic acid 4-carboxy-3-heptyl-5-hydroxyphenyl ester, respectively, on the basis of chemical and physico-chemical evidences.
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