Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery
Davide PantarottoDipartimento di Scienze Farmaceutiche, Università di Trieste, 34127 Trieste, ItalyRavi SinghCentre for Drug Delivery Research and Electron Microscopy Unit, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom,David McCarthyCentre for Drug Delivery Research and Electron Microscopy Unit, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom,Mathieu ErhardtInstitut de Biologie Moléculaire des Plantes, 67084 Strasbourg, FranceJean‐Paul BriandInstitut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France,Maurizio PratoDipartimento di Scienze Farmaceutiche, Università di Trieste, 34127 Trieste, Italy,Kostas KostarelosCentre for Drug Delivery Research and Electron Microscopy Unit, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom,Alberto BiancoInstitut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France,
2004en
ABI
Annotatsiya
Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA–nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.
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