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Sesquiterpene Coumarins from <i>Ferula Foetida</i>

Mohamed H. Abd El‐RazekYang‐Chang WuGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.CFang‐Rong ChangGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C
2007en
ABI

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Abstract A thorough investigation of the ethyl acetate soluble fraction from a methanol extract of the resin of Ferula foetida has resulted in the isolation of a new sesquiterpene coumarin namely epi ‐conferdione ( 1 ), along with four known compounds, colladonin ( 2 ), karatavicinol ( 3 ), 8‐acetoxy‐5‐hydroxyumbelliprenin ( 4 ), and asacoumarin ( 5 ). These structures were elucidated on the basis of extensive spectroscopic techniques, including 1D and 2D NMR spectroscopy. The absolute configuration of the new compound was established by circular dichroism (CD).

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