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Sesquiterpene Coumarins from <i>Ferula gumosa</i>

Mehrdad IranshahiBiotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, and Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, ItalyMilena MasulloBiotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, and Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, ItalyAli AsiliBiotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, and Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, ItalyAli HamedzadehBiotechnology Research CenterBentolhoda JahanbinBiotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, and Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, ItalyMichela FestaBiotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, and Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, ItalyAnna CapassoBiotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, and Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, ItalySonia PiacenteBiotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran, and Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
2010en
ABI

Annotatsiya

A new sesquiterpene coumarin, gumosin (1), two new sesquiterpene coumarin glycosides, gumosides A (2) and B (3), and 10 known compounds, namely, cauferoside (4), feselol (5), conferoside, ferilin, ferocaulidin, ligupersin A, conferol, and daucosterol, and the phenolic compounds acantrifoside E and 4-hydroxybenzoic acid 4-(6-O-sulfo)glucopyranoside, were isolated from a methanolic extract of Ferula gumosa roots. The structures of 1-3 were elucidated by spectroscopic data interpretation. The cytotoxic activity of the sesquiterpene coumarin derivatives was evaluated against a small panel of cancer cell lines.

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