A New Diterpenoid Alkaloid, Sharwuphinine A from Delphinium sharwurense

A new diterpenoid alkaloid, sharwuphinine A (1) was isolated from the aerial part of Delphinium sharwurense and the structure possessing a lycoctonine-type C 19 -diterpenoid alkaloid with a nitrone functionality was elucidated by spectroscopic analysis.Sharwuphinine A (1) showed moderate vasorelaxant activity on rat aorta.Delphinium species have been employed in analgesic balms, sedatives, emetics, and antihelminthics in folk medicine. 1About twenty species are distributed in Xinjiang Uygur autonomous region, People's Republic of China among approximately 300 species in the world.Diterpenoid alkaloids are the major active constituents of Delphinium plants belonging to Ranunculaceae.We have so far isolated several diterpenoid alkaloids such as elatine from Delphinium sharwurense W. T. Wang, 2 which showed muscle relaxing activity. 3On continuing search for chemical constituents of D. sharwurense with biological activity, we have isolated a new diterpenoid alkaloid with a nitrone functionality, sharwuphinine A (1), which showed moderate vasorelaxant activity against rat aorta.This paper describes the isolation and structure elucidation of 1 and vasodilator effect on rat aorta.22 21

Hali tarjima qilinmagan