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Synthesis of biocompatible multicolor luminescent carbon dots for bioimaging applications

Nagaprasad PuvvadaDepartment of Chemistry, Indian Institute of Technology, Kharagpur, West Bengal, 721302, IndiaB. N. Prashanth KumarSchool of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, 721302, IndiaSuraj KonarDepartment of Chemistry, Indian Institute of Technology, Kharagpur, West Bengal, 721302, IndiaHimani KalitaDepartment of Chemistry, Indian Institute of Technology, Kharagpur, West Bengal, 721302, IndiaMahitosh MandalSchool of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, 721302, IndiaAmita PathakDepartment of Chemistry, Indian Institute of Technology, Kharagpur, West Bengal, 721302, India
2012en
ABI

Annotatsiya

Water-soluble carbon dots (C-dots) were prepared through microwave-assisted pyrolysis of an aqueous solution of dextrin in the presence of sulfuric acid. The C-dots produced showed multicolor luminescence in the entire visible range, without adding any surface-passivating agent. X-ray diffraction and Fourier transform infrared spectroscopy studies revealed the graphitic nature of the carbon and the presence of hydrophilic groups on the surface, respectively. The formation of uniformly distributed C-dots and their luminescent properties were, respectively, revealed from transmission electron microscopy and confocal laser scanning microscopy. The biocompatible nature of C-dots was confirmed by a cytotoxicity assay on MDA-MB-468 cells and their cellular uptake was assessed through a localization study.

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