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Advances in therapeutic applications of extracellular vesicles

Oscar P. B. WiklanderDepartment of Laboratory Medicine, Karolinska Institutet, 141 86 Stockholm, SwedenMeadhbh Á. BrennanDepartments of Neurology and Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USAJan LötvallKrefting Research Centre, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, SwedenXandra O. BreakefieldDepartments of Neurology and Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USASamir EL AndaloussiDepartment of Laboratory Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden

2019en

ABI

Annotatsiya

Extracellular vesicles (EVs) are nanometer-sized, lipid membrane-enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions. Given their ability to transfer bioactive components and surmount biological barriers, EVs are increasingly being explored as potential therapeutic agents. EVs can potentiate tissue regeneration, participate in immune modulation, and function as potential alternatives to stem cell therapy, and bioengineered EVs can act as delivery vehicles for therapeutic agents. Here, we cover recent approaches and advances of EV-based therapies.

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DOI: 10.1126/scitranslmed.aav8521

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