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The Contribution of Angiogenesis to the Process of Metastasis

Diane R. BielenbergResearch reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award numbers R01CA037393 (to B.R.Z.) and R21CA155728 (to D.R.B.). These studies were also supported by the Vascular Biology Program at Boston Children’s HospitalBruce R. ZetterResearch reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award numbers R01CA037393 (to B.R.Z.) and R21CA155728 (to D.R.B.). These studies were also supported by the Vascular Biology Program at Boston Children’s Hospital

2015en

ABI

Annotatsiya

The role of angiogenesis in tumor growth has been studied continuously for over 45 years. It is now appreciated that angiogenesis is also essential for the dissemination and establishment of tumor metastases. In this review, we focus on the role of angiogenesis as a necessity for the escape of tumor cells into the bloodstream and for the establishment of metastatic colonies in secondary sites. We also discuss the role of tumor lymphangiogenesis as a means of dissemination of lymphatic metastases. Appropriate combination therapies may be used in the future to both prevent and treat metastatic disease through the rational use of antiangiogenic and antilymphangiogenic therapies in ways that are informed by the current and future work in the field.

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Identifikatorlar

DOI: 10.1097/ppo.0000000000000138

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