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Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression

Nasrin Ahangar DavoodiEye Research Center, Rassoul Akram Hospital, Tehran University of Medical Sciences, Tehran, IranSajad NajafiDepartment of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranZari Naderi Ghale-NoieDepartment of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranAshkan PiranvisehBrain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, IranSamaneh MollazadehNatural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, IranSahar Ahmadi AsouriResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranZatollah AsemiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranMohammadamin MorshediSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranSeyed Saeed Tamehri ZadehSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranMichael R. HamblinLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South AfricaAmirhossein SheidaSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranHamed MirzaeiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

2022en

ABI

Annotatsiya

Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that has the potential to affect vision, and can even be fatal in some children. While the tumor can be controlled efficiently at early stages, metastatic tumors lead to high mortality. Non-coding RNAs (ncRNAs) are implicated in a number of physiological cellular process, including differentiation, proliferation, migration, and invasion, The deregulation of ncRNAs is correlated with several diseases, particularly cancer. ncRNAs are categorized into two main groups based on their length, i.e. short and long ncRNAs. Moreover, ncRNA deregulation has been demonstrated to play a role in the pathogenesis and development of RB. Several ncRNAs, such as miR-491-3p, miR-613,and SUSD2 have been found to act as tumor suppressor genes in RB, but other ncRNAs, such as circ-E2F3, NEAT1, and TUG1 act as tumor promoter genes. Understanding the regulatory mechanisms of ncRNAs can provide new opportunities for RB therapy. In the present review, we discuss the functional roles of the most important ncRNAs in RB, their interaction with the genes responsible for RB initiation and progression, and possible future clinical applications as diagnostic and prognostic tools or as therapeutic targets.

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Identifikatorlar

DOI: 10.3389/fcell.2022.1065837

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