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Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

Jie YangJ. Yang, X. Liu, C. N. Kim, J. Cai, D. P. Jones, X. Wang, Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USAXuesong LiuJ. Yang, X. Liu, C. N. Kim, J. Cai, D. P. Jones, X. Wang, Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USAKapil N. BhallaK. Bhalla and A. Ibrado, Division of Hematology-Oncology, Department of Medicine, Winship Cancer Center, Emory University School of Medicine, Atlanta, GA 30322, USACaryn Naekyung KimJ. Yang, X. Liu, C. N. Kim, J. Cai, D. P. Jones, X. Wang, Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USAAna Maria IbradoK. Bhalla and A. Ibrado, Division of Hematology-Oncology, Department of Medicine, Winship Cancer Center, Emory University School of Medicine, Atlanta, GA 30322, USAJiyang CaiJ. Yang, X. Liu, C. N. Kim, J. Cai, D. P. Jones, X. Wang, Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USATsung-I PengT.-I Peng, Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USADean P. JonesJ. Yang, X. Liu, C. N. Kim, J. Cai, D. P. Jones, X. Wang, Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USAXiaodong WangJ. Yang, X. Liu, C. N. Kim, J. Cai, D. P. Jones, X. Wang, Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA

1997en

ABI

Annotatsiya

Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in response to a variety of stimuli. Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and cytochrome c, which is normally located in the mitochondrial intermembrane space. Cells undergoing apoptosis were found to have an elevation of cytochrome c in the cytosol and a corresponding decrease in the mitochondria. Overexpression of Bcl-2 prevented the efflux of cytochrome c from the mitochondria and the initiation of apoptosis. Thus, one possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria.

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DOI: 10.1126/science.275.5303.1129

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