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Anti-HIV-1 Protease Triterpenoid Saponins from the Seeds of <i>Aesculus</i> <i>chinensis</i>

Xiu‐Wei YangNational Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, People's Republic of China, and Research Institute for Wakan-Yuku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, JapanJing ZhaoNational Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, People's Republic of China, and Research Institute for Wakan-Yuku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, JapanYuxin CuiNational Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, People's Republic of China, and Research Institute for Wakan-Yuku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, JapanXuehui LiuNational Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, People's Republic of China, and Research Institute for Wakan-Yuku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, JapanChao‐Mei MaNational Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, People's Republic of China, and Research Institute for Wakan-Yuku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, JapanMasao HattoriNational Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, People's Republic of China, and Research Institute for Wakan-Yuku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, JapanLihe ZhangNational Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, People's Republic of China, and Research Institute for Wakan-Yuku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan

1999en

ABI

Annotatsiya

Eight bioactive triterpenoid saponins (1-8) were isolated from the seeds of Aesculus chinensis, four of which are novel compounds. The major saponins were identified as escin Ia (1), Ib (2), isoescin Ia (3) and Ib (4), while the new compounds were identified as 22alpha-tigloyl-28-acetylprotoaescigenin-3beta-O-¿beta -D-glucopyranos yl (1-2) ¿beta-D-glucopyranosyl (1-4)-beta-D-glucopyranosiduronic acid (escin IVc, 5), 22alpha-angeloyl-28-acetylprotoaescigenin-3beta-O-¿bet a-D-glucopyrano syl (1-2) ¿beta-D-glucopyranosyl (1-4)-beta-D-glucopyranosiduronic acid (escin IVd, 6), 28-tigloylprotoaescigenin-3beta-O-¿beta-D-glucopyranosyl (1-2) ¿beta-D-glucopyranosyl (1-4)-beta-D-glucopyranosiduronic acid (escin IVe, 7), and 28-angeloylprotoaescigenin-3beta-O-¿beta-D-glucopyranosyl (1-2) ¿beta-D-glucopyranosyl (1-4)-beta-D-glucopyranosiduronic acid (escin IVf, 8). The structures were determined by chemical and spectroscopic methods. All the above compounds were evaluated for their inhibitory activity against HIV-1 protease.

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DOI: 10.1021/np990180u

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