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The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. LouisDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USAArie PerryDepartment of Pathology, University of California San Francisco, San Francisco, California, USAPieter WesselingDepartment of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, the NetherlandsDaniel J. BratDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USAIan A. CreeInternational Agency for Research on Cancer, World Health Organization, Lyon, FranceDominique Figarella‐BrangerService d’Anatomie Pathologique et de Neuropathologie, APHM, CNRS, Institut de Neurophysiopathologie, Hôpital de la Timone, Aix-Marseille University, Marseille, FranceCynthia HawkinsDepartment of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaHo‐Keung NgDepartment of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, ChinaStefan M. PfisterHopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Division of Pediatric Neurooncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), and Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, GermanyGuido ReifenbergerInstitute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University Düsseldorf, and German Cancer Consortium (DKTK) Partner Site Essen/Düsseldorf, Düsseldorf, GermanyRiccardo SoffiettiDepartment of Neurology and Neuro-Oncology, University of Turin Medical School, Turin, ItalyAndreas von DeimlingClinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK), Heidelberg, GermanyDavid W. EllisonDepartment of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

2021en

ABI

Annotatsiya

The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the international standard for the classification of brain and spinal cord tumors. Building on the 2016 updated fourth edition and the work of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy, the 2021 fifth edition introduces major changes that advance the role of molecular diagnostics in CNS tumor classification. At the same time, it remains wedded to other established approaches to tumor diagnosis such as histology and immunohistochemistry. In doing so, the fifth edition establishes some different approaches to both CNS tumor nomenclature and grading and it emphasizes the importance of integrated diagnoses and layered reports. New tumor types and subtypes are introduced, some based on novel diagnostic technologies such as DNA methylome profiling. The present review summarizes the major general changes in the 2021 fifth edition classification and the specific changes in each taxonomic category. It is hoped that this summary provides an overview to facilitate more in-depth exploration of the entire fifth edition of the WHO Classification of Tumors of the Central Nervous System.

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Identifikatorlar

DOI: 10.1093/neuonc/noab106

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