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Infection of orthopedic implants and the use of antibiotic-loaded bone cements: A review

Hilbrand van de BeltDepartment of Orthopedic Surgery, University Hospital Groningen, The NetherlandsDaniëlle NeutDepartments of Orthopedic Surgery, University Hospital Groningen, Hanzeplein 1, NL-9713 GZ Groningen, The Netherlands, Biomedical Engineering, University of Groningen, Antonius Deusinglaan 1, NL- 9713 AV Groningen, The Netherlands. Correspondence: Dr. J. R. van Horn, Department of Orthopedic Surgery. E-mail: [email protected]Willem SchenkDepartments of Orthopedic Surgery, University Hospital Groningen, Hanzeplein 1, NL-9713 GZ Groningen, The Netherlands, Biomedical Engineering, University of Groningen, Antonius Deusinglaan 1, NL- 9713 AV Groningen, The Netherlands. Correspondence: Dr. J. R. van Horn, Department of Orthopedic Surgery. E-mail: [email protected]Jim R. van HornDepartments of Orthopedic Surgery, University Hospital Groningen, Hanzeplein 1, NL-9713 GZ Groningen, The Netherlands, Biomedical Engineering, University of Groningen, Antonius Deusinglaan 1, NL- 9713 AV Groningen, The Netherlands. Correspondence: Dr. J. R. van Horn, Department of Orthopedic Surgery. E-mail: [email protected]Henny C. van der MeiDepartments of Orthopedic Surgery, University Hospital Groningen, Hanzeplein 1, NL-9713 GZ Groningen, The Netherlands, Biomedical Engineering, University of Groningen, Antonius Deusinglaan 1, NL- 9713 AV Groningen, The Netherlands. Correspondence: Dr. J. R. van Horn, Department of Orthopedic Surgery. E-mail: [email protected]Henk J. BusscherDepartments of Orthopedic Surgery, University Hospital Groningen, Hanzeplein 1, NL-9713 GZ Groningen, The Netherlands, Biomedical Engineering, University of Groningen, Antonius Deusinglaan 1, NL- 9713 AV Groningen, The Netherlands. Correspondence: Dr. J. R. van Horn, Department of Orthopedic Surgery. E-mail: [email protected]

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ABI

Annotatsiya

Infections by bacteria are a serious complication following orthopedic implant surgery, that can usually only be cured by removing the implant, since the biofilm mode of growth of infecting bacteria on an implant surface protects the organisms from the host immune system and antibiotic therapy. Over the past few decades, attempts have been made to prevent and cure orthopedic implant infections by incorporating antibiotics in polymethylmethacrylate bone cements, in primary and revision surgery. However, the clinical efficacy of antibiotic-releasing bone cements is not accepted by all and the long-term exposure to low doses from antibiotic-releasing bone cements in patients is strongly related to the emerging threat of antibiotic resistance in medicine today. In this article, we start by reviewing the mechanisms governing the formation of an infectious biofilm on orthopedic implant materials, the release mechanisms and properties of clinically-used, antibiotic-loaded bone cements. The clinical efficacy of antibiotic-loaded bone cements is evaluated analyzing separatedly the prophylactic and therapeutic uses of these products.

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Identifikatorlar

DOI: 10.1080/000164701317268978

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