Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
Simin TangThe Second People's Hospital of Huai'an, Huai'an, China; Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaXueting DengMedical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaJian ZhouMedical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China; Department of Gastrointestinal Endoscopy, Nanjing Medical University, Nanjing, ChinaQuanpeng LiMedical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China; Department of Gastrointestinal Endoscopy, Nanjing Medical University, Nanjing, ChinaXianxiu GeMedical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China; Department of Gastrointestinal Endoscopy, Nanjing Medical University, Nanjing, ChinaLin MiaoMedical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China; Department of Gastrointestinal Endoscopy, Nanjing Medical University, Nanjing, China. Electronic address: [email protected]
2019en
ABI
Annotatsiya
Quercetin is a kind of flavonoid compounds that comes from nature and is widely existed in the daily diet. Previous studies have found that quercetin has many effects such as anti-inflammatory, anti-oxidation and anti-cancer. Both in vivo and in vitro experiments have demonstrated that quercetin can exert anti-tumor effects by altering cell cycle progression, inhibiting cell proliferation, promoting apoptosis, inhibiting angiogenesis and metastasis progression, and affecting autophagy. This review summarizes the evidence for the pharmacological potential and inhibition of quercetin on cancers, supporting the viewpoint that quercetin should be adequately considered as a therapeutic agent against various cancers.
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