A Guide to ComBat Harmonization of Imaging Biomarkers in Multicenter Studies
Fanny OrlhacLITO-U1288, Institut Curie, Université PSL, Université Paris-Saclay, Inserm, Orsay, France; [email protected]Jakoba J. EertinkAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, Amsterdam, The NetherlandsAnne‐Ségolène CottereauDepartment of Nuclear Medicine, Hôpital Cochin, Université Paris-Descartes, APHP, Paris, FranceJosée M. ZijlstraAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, Amsterdam, The NetherlandsCatherine ThiéblemontDepartment of Hemato-Oncology, Hôpital Saint-Louis, DMU DHI, Université de Paris, APHP, Paris, FranceMichel MeignanLymphoma Study AssociationRonald BoellaardVrije Universiteit AmsterdamIrène BuvatLITO-U1288, Institut Curie, Université PSL, Université Paris-Saclay, Inserm, Orsay, France
2021en
ABI
Annotatsiya
The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This scanner effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met and, thus, in which ComBat should not be used.
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