Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)
Chuanhao JiangDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaTaoli SunKey Laboratory Breeding Base of Hu'nan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, College of Pharmacy, Changsha Medical University, Changsha, ChinaDaxiong XiangDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, ChinaShanshan WeiDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, ChinaWen‐Qun LiDepartment of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China
2018en
ABI
Annotatsiya
It has been observed that many phytochemicals, frequently present in foods or beverages, show potent chemopreventive or therapeutic properties that selectively affect cancer cells. Numerous studies have demonstrated the anticancer activity of xanthohumol (Xn), a prenylated flavonoid isolated from hops (Humulus lupulus L.), with a concentration up to 0.96 mg/L in beer. This review aims to summarize the existing studies focusing on the anticancer activity of Xn and its effects on key signaling molecules. Furthermore, the limitations of current studies and challenges for the clinical use of Xn are discussed.
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