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Resveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological properties

Eric Wei Chiang ChanFaculty of Applied Sciences, UCSI University, Kuala Lumpur, MalaysiaChen Wai WongFaculty of Applied Sciences, UCSI University, Kuala Lumpur, MalaysiaYong Hui TanFaculty of Applied Sciences, UCSI University, Kuala Lumpur, MalaysiaJenny Pei Yan FooFaculty of Applied Sciences, UCSI University, Kuala Lumpur, MalaysiaSiu Kuin WongSchool of Science, Monash University Sunway, Selangor, MalaysiaHung Tuck ChanSecretariat, International Society for Mangrove Ecosystems (ISME), Faculty of Agriculture, University of the Ryukyus, Okinawa, Japan

2019en

ABI

Annotatsiya

Both resveratrol and pterostilbene are monomeric stilbenes having a 6-2-6 carbon skeleton with two phenyl rings linked by a double-bonded ethylene bridge. Resveratrol has three hydroxyl (-OH) groups, while pterostilbene has two methoxy (-OCH 3 ) groups and one -OH group. They commonly occur in the trans form rather than the cis form. Red grapes and red wines are the main dietary sources of the resveratrol. Pterostilbene occurs in blueberries and grapes. Resveratrol and pterostilbene exhibit many similarities in pharmacological properties, including antioxidant, neuroprotective anti-cancer, cardioprotective, analgesic, anti-atherosclerosis, anti-aging, anti-diabetic, antiinflammatory, and anti-obesity activities. The stronger pharmacological properties in pterostilbene than resveratrol have been attributed to its two -OCH 3 groups. As a result, pterostilbene is more lipophilic which enhances its membrane permeability, bioavailability, and biological potency. Some future studies on resveratrol and pterostilbene are suggested.

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Identifikatorlar

DOI: 10.7324/japs.2019.90717

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