Breast cancer-derived DAMPs enhance cell invasion and metastasis, while nucleic acid scavengers mitigate these effects
Elias EtesholaDuke University Medical Center, Department of Surgery, Durham, NC 27710, USAKarenia LandaDuke University Medical Center, Department of Surgery, Durham, NC 27710, USARachel E. RempelDuke University Medical Center, Department of Surgery, Durham, NC 27710, USAIbtehaj A. NaqviDuke University Medical Center, Department of Surgery, Durham, NC 27710, USAE. Shelley HwangDuke University Medical Center, Department of Surgery, Durham, NC 27710, USASmita K. NairDuke Cancer Institute, Durham, NC 27710, USABruce A. SullengerDuke Cancer Institute, Durham, NC 27710, USA
2021en
ABI
Annotatsiya
. Notably, treatment with the polyamidoamine dendrimer generation 3.0 (PAMAM-G3) behaved as a nucleic acid scavenger (NAS) and significantly mitigates such effects. In mice that develop spontaneous BC induced by polyoma middle T oncoprotein (MMTV-PyMT), treatment with PAMAM-G3 significantly reduces lung metastasis. Thus, NAS treatment mitigates cancer-induced inflammation and metastasis and represents a novel therapeutic approach for combating breast cancer.
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