Sharh maqola

NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers

Yujie ZhouSchool of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaSongyan YuSchool of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaWenyong ZhangKey University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China

2023en

ABI

Annotatsiya

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated molecular patterns, trigger numerous signaling pathways and lead to the secretion of various cytokines. In recent years, cumulative studies have revealed the significant impacts of NLRs in gastrointestinal (GI) inflammatory diseases and cancers. Deciphering the role and molecular mechanism of the NLR signaling pathways may provide new opportunities for the development of therapeutic strategies related to GI inflammatory diseases and GI cancers. This review presents the structures and signaling pathways of NLRs, summarizes the recent advances regarding NLR signaling in GI inflammatory diseases and GI cancers and describes comprehensive therapeutic strategies based on this signaling pathway.

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.3390/ijms241914511

Iqtiboslar va manbalar

2 ta iqtibos0 ta foydalanilgan manba

Koʻrsatkichlar — AkademScholar