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Solubility of Dexamethasone in Supercritical Carbon Dioxide with and without a Cosolvent

Chuan TangDepartment of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaYi‐Xin GuanDepartment of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaShan‐Jing YaoDepartment of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaZiqiang ZhuDepartment of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China

2014en

ABI

Annotatsiya

The solubility of dexamethasone, a synthetic glucocorticoid, in supercritical CO2 and together with 3.0 mol % ethanol as a cosolvent was measured at different temperatures (313.2, 318.2, and 323.2) K and pressures ranging from (10.0 to 25.0) MPa by a static analytical method. The obtained solubility of dexamethasone was between 1.19·10–6 and 1.52·10–6 in pure supercritical CO2 and between 1.97·10–6 and 2.98·10–6 in supercritical CO2 with a cosolvent. The experimental data in supercritical CO2 in the absence and presence of a cosolvent were correlated using four density-based semiempirical models, that is, Chrastil, Kumar and Johnston, Bartle, and Méndez-Santiago and Teja models. The results indicated that the Kumar and Johnston model gave a better correlated result than the other three with an average absolute relative deviation [AARD (%)] value lower than 2.15 %.

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DOI: 10.1021/je500345n

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