Maqola

Determination of the Solubility of the Repaglinide Drug in Supercritical Carbon Dioxide: Experimental Data and Thermodynamic Modeling

Gholamhossein SodeifianDepartment of Chemical Engineering, Laboratory of Supercritical Fluids and Nanotechnology and Modeling and Simulation Centre, Faculty of Engineering, Faculty of Engineering, University of Kashan, 87317-53153 Kashan, IranSeyed Mojtaba HazaveieDepartment of Chemical Engineering, Laboratory of Supercritical Fluids and Nanotechnology and Modeling and Simulation Centre, Faculty of Engineering, Faculty of Engineering, University of Kashan, 87317-53153 Kashan, IranSeyed Ali SajadianSouth Zagros Oil and Gas Production, National Iranian Oil Company, 7135717991 Shiraz, IranNedasadat Saadati ArdestaniDepartment of Chemical Engineering, Laboratory of Supercritical Fluids and Nanotechnology and Modeling and Simulation Centre, Faculty of Engineering, Faculty of Engineering, University of Kashan, 87317-53153 Kashan, Iran

2019en

ABI

Annotatsiya

In the recent few years, the measurement, correlation, and calculation of solid solubility, especially drugs, in supercritical fluids have been increased. Evaluation of solubility of a solid solute drug in supercritical fluids is a major factor in the production of nanosized particles. In this research, the solubility of repaglinide (RPL; antidiabetic drug) was measured for the first time. Experiments was fulfilled at various temperatures (308–338 K) and pressures (120–270 bar). It was found that the solubility of RPL is within the range of 2.899 × 10–6 to 9.529 × 10–5. Peng–Robinson and UNIQUAC as well as six semi-empirical models, including Sodeifian et al., Bartle et al., Chrastil, Méndez-Santiago–Teja, Garlapati–Madras, and Kumar–Johnston, was applied to model the solubility behavior. Moreover, self-consistency tests were carried out to discover the RPL solubility in SC-CO2. Finally, the approximate values of total (ΔHtotal), vaporization (ΔHvap), and solvation (ΔHsol) enthalpies were computed.

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.1021/acs.jced.9b00550

Iqtiboslar va manbalar

3 ta iqtibos0 ta foydalanilgan manba

Koʻrsatkichlar — AkademScholar