Nanomedicine Formulation Using Green Supercritical Processing: Experimental Solubility Measurement and Theoretical Investigation
Fatemeh ArabgolBuein Zahra Technical University Department of Chemical and Materials Engineering P.O. Box: 34518-66391 Buein Zahra, Qazvin IranMitra AmaniIslamic Azad University Department of Chemical Engineering, Robat Karim Branch P.O. Box: 37616-16461 Robat Karim IranNedasadat Saadati ArdestaniResearch Institute of Petroleum Industry (RIPI) Nanotechnology Research Center P.O. Box: 14857-336 Tehran IranSeyed Ali SajadianUniversity of Kashan Department of Chemical Engineering, Faculty of Engineering P.O. Box: 87317-53153 Kashan Iran
2023en
ABI
Annotatsiya
Abstract To develop effective pharmaceutical formulations using supercritical carbon dioxide (scCO 2 ) techniques, it is necessary to obtain the solubility of the medicinal ingredients in scCO 2 . In the current study, the solubility of Amantadine in scCO 2 was evaluated under 28 different operating conditions involving seven pressures and four temperatures. To theoretically study this process, some popular empirical models and two well‐known thermodynamic models (PR‐WS and PC‐SAFT) were examined. The results suggest that the PR‐WS and PC‐SAFT models are the most accurate in establishing a correlation of the solubility of Amantadine in scCO 2 .
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