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Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance

Xiaolin WangDepartment of Clinical Laboratory, The First Affiliated Hospital of USTC, Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China (UTSC), Hefei, 230027, Anhui, ChinaJiahui ZhangHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science (HIPS), Chinese Academy of Sciences, Hefei, 230031, Anhui, ChinaGuozhen CaoHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science (HIPS), Chinese Academy of Sciences, Hefei, 230031, Anhui, ChinaJinghan HuaHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science (HIPS), Chinese Academy of Sciences, Hefei, 230031, Anhui, ChinaGe ShanDepartment of Clinical Laboratory, The First Affiliated Hospital of USTC, Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China (UTSC), Hefei, 230027, Anhui, China. [email protected]Wenchu LinHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science (HIPS), Chinese Academy of Sciences, Hefei, 230031, Anhui, China. [email protected]

2022en

ABI

Annotatsiya

Gastric cancer (GC) is an aggressive malignancy with a high mortality rate and poor prognosis, primarily caused by metastatic lesions. Improved understanding of GC metastasis at the molecular level yields meaningful insights into potential biomarkers and therapeutic targets. Covalently closed circular RNAs (circRNAs) have emerged as crucial regulators in diverse human cancers including GC. Furthermore, accumulating evidence has demonstrated that circRNAs exhibit the dysregulated patterns in GC and have emerged as crucial regulators in GC invasion and metastasis. However, systematic knowledge regarding the involvement of circRNAs in metastatic GC remains obscure. In this review, we outline the functional circRNAs related to GC metastasis and drug resistance and discuss their underlying mechanisms, providing a comprehensive delineation of circRNA functions on metastatic GC and shedding new light on future therapeutic interventions for GC metastases.

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DOI: 10.1186/s13046-022-02432-z

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