Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis
Yu Suna Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. ChinaWenzhou Liua Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. ChinaTao Liua Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. ChinaFeng Xua Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. ChinaNuo Yanga Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. ChinaHua‐Fu Zhoua Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. China
2015en
ABI
Annotatsiya
The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.
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