Maqola

The estimated disease burden of acute COVID-19 in the Netherlands in 2020, in disability-adjusted life-years

Scott McDonaldCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [email protected]Giske LagerweijCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsPieter de BoerCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsHester E. de MelkerCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsRoan PijnackerCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsLapo Mughini GrasCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsMirjam KretzschmarCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsGerco den HartogCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsArianne B. van Gageldonk‐LafeberCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsRIVM COVID-19 surveillance, epidemiology teamAgnetha HofhuisCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsAnne TeirlinckAlies van LierBronke BoudewijnsMiek de DreuAnne-Wil ValkFemke JongenotterCarolien VerstratenGert BroekhaarGuido WillekensIrene VeldhuijzenJ. PolmanJan van de KassteeleJ.L. Blussé van Oud AlblasJanneke van HeereveldJanneke C. M. HeijneKirsten BulsinkLieke WieldersLiselotte van AstenLiz JenniskensLoes SoetensMaarten MulderMaarten SchipperMarit de LangeNaomi SmorenburgNienke NeppelenbroekPatrick van den BergPriscila de Oliveira Bressane LimaRolina van GaalenSara WijburgShahabeh Abbas Zadeh Siméon de BruijnSenna van IerselStijn P. AndewegSjoerd WierengaCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsSusan LanooijS. F. A. KeijserTara SmitCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsDon KlinkenbergJantien A. BackerCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsPieter de BoerCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsAmber MaxwellAnnabel NiessenBrechje de GierDanytza BerryDaphne van WeesDimphey van MeijerenEric R. A. VosFrederika DijkstraJeanet M. KemmerenKylie E. C. AinslieMarit MiddeldorpMarjolein N. KooijmanUniversity Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsMirjam J. KnolTimor FaberA. HoekEveline GeubbelsBirgit van BenthemCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsJacco WallingaCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsArianne B. van Gageldonk‐LafeberCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsSusan HahnéCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsSusan van den HofCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The NetherlandsSusan van den fCenter for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

2022en

ABI

Annotatsiya

The impact of COVID-19 on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires hospital and/or ICU admission, results in prolonged and chronic illness, or leads to premature death. We aimed to quantify the total disease burden of acute COVID-19 in the Netherlands in 2020 using the disability-adjusted life-years (DALY) measure, and to investigate how burden varies between age-groups and occupations. Using standard methods and diverse data sources (mandatory notifications, population-level seroprevalence, hospital and ICU admissions, registered COVID-19 deaths, and the literature), we estimated years of life lost (YLL), years lived with disability, DALY and DALY per 100,000 population due to COVID-19, excluding post-acute sequelae, stratified by 5-year age-group and occupation category. The total disease burden due to acute COVID-19 was 286,100 (95% CI: 281,700-290,500) DALY, and the per-capita burden was 1640 (95% CI: 1620-1670) DALY/100,000, of which 99.4% consisted of YLL. The per-capita burden increased steeply with age, starting from 60 to 64 years, with relatively little burden estimated for persons under 50 years old. SARS-CoV-2 infection and associated premature mortality was responsible for a considerable direct health burden in the Netherlands, despite extensive public health measures. DALY were much higher than for other high-burden infectious diseases, but lower than estimated for coronary heart disease. These findings are valuable for informing public health decision-makers regarding the expected COVID-19 health burden among population subgroups, and the possible gains from targeted preventative interventions.

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.1007/s10654-022-00895-0

Iqtiboslar va manbalar

2 ta iqtibos0 ta foydalanilgan manba

Koʻrsatkichlar — AkademScholar