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Toxicological Studies on Silver Nanoparticles: Challenges and Opportunities in Assessment, Monitoring and Imaging

Matthew StensbergDepartment of Agricultural & Biological Engineering, Purdue University, 225 S University St, West Lafayette, IN47907, USAQingshan WeiDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN47907, USAEric S. McLamoreAgricultural & Biological Engineering Department, University of Florida, 105 Frazier Rogers Hall, PO Box 110570, Gainesville, FL32611, USAD. Marshall PorterfieldDepartment of Agricultural & Biological Engineering, Purdue University, 225 S University St, West Lafayette, IN47907, USAAlexander WeiDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN47907, USAMarı́a S. SepúlvedaDepartment of Forestry & Natural Resources, Purdue University, 195 Marsteller St, West Lafayette, IN 47907, USA

2011en

ABI

Annotatsiya

Silver nanoparticles (Ag NPs) are becoming increasingly prevalent in consumer products as antibacterial agents. The increased use of Ag NP-enhanced products may lead to an increase in toxic levels of environmental silver, but regulatory control over the use or disposal of such products is lagging due to insufficient assessment on the toxicology of Ag NPs and their rate of release into the environment. In this article we discuss recent research on the transport, activity and fate of Ag NPs at the cellular and organismic level, in conjunction with traditional and recently established methods of nanoparticle characterization. We include several proposed mechanisms of cytotoxicity based on such studies, as well as new opportunities for investigating the uptake and fate of Ag NPs in living systems.

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Identifikatorlar

DOI: 10.2217/nnm.11.78

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